Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596293 | 0.84 | ESR1 (0.48) | ESR1THRBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL8182988 | 0.78 | ALDH1A1 (0.46) | THRBL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL19704633 | 0.77 | TRPV1 (0.34) | THRBL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL8168872 | 0.76 | HRH3 (0.41) | THRBL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL16240889 | 0.74 | ESR1 (0.56) | ESR1THRBL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL24419592 | 0.74 | LMNA (0.45) | ESR1THRBCYP3A4TSHRHSD17B10 | |
| SCHEMBL26005653 | 0.74 | TSHR (0.41) | THRBL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL6685103 | 0.73 | ESR1 (0.74) | ESR1THRBTDP1ALDH1A1CYP3A4 | |
| SCHEMBL21799723 | 0.73 | MAPT (0.39) | THRBL3MBTL1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL13233319 | 0.73 | ESR1 (0.54) | ESR1THRBALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787480-B2 | Cytotoxic peptides and conjugates thereof | NOVARTIS AG (CH) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787480-B2 | Cytotoxic peptides and conjugates thereof | CD47, NGLY1, VIP | ESR1 3967/4885THRB 3616/4885L3MBTL1 2207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.