Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22472758 | 0.91 | MAPT (0.37) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22472754 | 0.88 | KDM4E (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22472767 | 0.87 | ADORA2A (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22472802 | 0.86 | NPC1 (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22472774 | 0.82 | ALDH1A1 (0.42) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22472790 | 0.81 | KDM4E (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22472769 | 0.79 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL25584699 | 0.78 | CA12 (0.34) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22472807 | 0.77 | KDM4E (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL23901594 | 0.76 | ALDH1A1 (0.42) | ALDH1A1RAB9ASMN1; SMN2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10786508-B2 | Substituted imidazo[1,5-A]-pyrimidines and their use in the treatment of medical disorders | LYSOSOMAL THERAPEUTICS INC. (US) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10786508-B2 | Substituted imidazo[1,5-A]-pyrimidines and their use in the treatment of medical disorders | GBA1, GAA, SNCA | ALDH1A1 1025/4885NPC1 823/4885RAB9A 1395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.