Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22472769 | 0.88 | ALDH1A1 (0.38) | ALDH1A1KDM4EADORA2ARAB9ASMN1; SMN2 | |
| SCHEMBL22472758 | 0.85 | MAPT (0.37) | ALDH1A1KDM4ENAMPTADORA2ARAB9A | |
| SCHEMBL23901523 | 0.85 | ABCB1 (0.42) | RAB9ASMN1; SMN2MCL1TP53 | |
| SCHEMBL23901684 | 0.82 | CNR1 (0.38) | ALDH1A1MAPK1MAPTNPSR1HSD17B10 | |
| SCHEMBL23901593 | 0.81 | PTGIR (0.42) | ALDH1A1KDM4ENAMPTRAB9ASMN1; SMN2 | |
| SCHEMBL22472754 | 0.79 | KDM4E (0.39) | ALDH1A1KDM4EADORA2ARAB9ASMN1; SMN2 | |
| SCHEMBL22472802 | 0.78 | NPC1 (0.38) | ALDH1A1KDM4EADORA2ARAB9ASMN1; SMN2 | |
| SCHEMBL21479246 | 0.77 | MAPT (0.39) | ALDH1A1KDM4ENAMPTCACNA1BAPBA1 | |
| SCHEMBL23901595 | 0.77 | CRHR1 (0.38) | ALDH1A1KDM4ENAMPTADORA2AMAPK1 | |
| SCHEMBL22472805 | 0.77 | MAPT (0.42) | KDM4EADORA2AMAPTNPSR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309661-A1 | IMIDAZO[1,5-a]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | BIAL - R&D INVESTMENTS, S.A. (PT) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309661-A1 | IMIDAZO[1,5-a]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | GBA1, GAA, GBA2 | ALDH1A1 1121/4885KDM4E 659/4885NAMPT 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.