Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CFB | P00751 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22473207 | 1.00 | RIPK1 (0.38) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL22473317 | 1.00 | RIPK1 (0.38) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL22473141 | 0.88 | CFB (0.37) | CFBMAOAMAOBCYP2D6CHRM1 | |
| SCHEMBL23491491 | 0.88 | CFB (0.37) | CFBMAOAMAOBCYP2D6CHRM1 | |
| SCHEMBL23491512 | 0.83 | CHRNB2 (0.49) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL23493302 | 0.80 | CHRNB2 (0.36) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL22473206 | 0.80 | CHRNB2 (0.36) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL22473396 | 0.79 | RIPK1 (0.43) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL22473394 | 0.79 | RIPK1 (0.43) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL22473388 | 0.79 | RIPK1 (0.43) | RIPK1CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210171516-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-06-10 | — | — | US | disclosed |
| US-10787446-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787446-B2 | Therapeutic compounds and methods of use thereof | AVPR1B, C3AR1, RHEB | RIPK1 3202/4885CHRNB2 1972/4885CHRNB4 2227/4885 |
| US-20210171516-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AVPR1B, C3AR1, RHEB | RIPK1 3202/4885CHRNB2 1972/4885CHRNB4 2227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.