Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.39 |
| ▸ | BTK | Q06187 | 7/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13067829 | 0.95 | JAK3 (0.42) | JAK3BTKEGFRJAK1JAK2 | |
| SCHEMBL16123470 | 0.95 | JAK3 (0.42) | JAK3BTKEGFRJAK1JAK2 | |
| SCHEMBL16123340 | 0.95 | JAK3 (0.42) | JAK3BTKEGFRJAK1JAK2 | |
| SCHEMBL17833391 | 0.87 | JAK3 (0.40) | JAK3BTKJAK1 | |
| SCHEMBL17833394 | 0.87 | JAK3 (0.40) | JAK3BTKJAK1 | |
| SCHEMBL17833396 | 0.87 | JAK3 (0.40) | JAK3BTKJAK1 | |
| SCHEMBL23866200 | 0.80 | TEAD1 (0.38) | JAK3BTKEGFRJAK1JAK2 | |
| SCHEMBL19240725 | 0.79 | ALDH1A1 (0.49) | JAK3BTK | |
| SCHEMBL19240724 | 0.79 | ALDH1A1 (0.49) | JAK3BTK | |
| SCHEMBL19240726 | 0.79 | ALDH1A1 (0.49) | JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3715346-A1 | THIAZOLYL-CONTAINING COMPOUNDS FOR TREATING PROLIFERATIVE DISEASES | Dana-Farber Cancer Institute (US) | 2020-09-30 | — | — | EP | disclosed |