Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.38 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 9/20 | 0.37 |
| ▸ | BTK | Q06187 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12163604 | 0.92 | TEAD1 (0.42) | TEAD1TEAD3JAK3BTKJAK1 | |
| Hydrochloric Acid SCHEMBL28635929 | 0.90 | GNAI3 (0.42) | TEAD1TEAD3JAK3BTKJAK1 | |
| SCHEMBL16123470 | 0.85 | JAK3 (0.42) | JAK3BTKJAK1EGFRJAK2 | |
| SCHEMBL13067829 | 0.85 | JAK3 (0.42) | JAK3BTKJAK1EGFRJAK2 | |
| SCHEMBL16123340 | 0.85 | JAK3 (0.42) | JAK3BTKJAK1EGFRJAK2 | |
| SCHEMBL17833396 | 0.81 | JAK3 (0.40) | TEAD1JAK3BTKJAK1 | |
| SCHEMBL17833391 | 0.81 | JAK3 (0.40) | TEAD1JAK3BTKJAK1 | |
| SCHEMBL17833394 | 0.81 | JAK3 (0.40) | TEAD1JAK3BTKJAK1 | |
| SCHEMBL22474744 | 0.80 | JAK3 (0.39) | JAK3BTKJAK1EGFRJAK2 | |
| SCHEMBL29728768 | 0.78 | TEAD1 (0.43) | TEAD1TEAD3JAK3BTKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |