Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.37 |
| ▸ | HINT1 | P49773 | 1/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | AHCY | P23526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23010195 | 0.84 | NT5E (0.36) | SLC29A1 | |
| SCHEMBL20754387 | 0.80 | SLC29A1 (0.33) | ADORA3ADORA1ADORA2AADORA2BSLC29A1 | |
| SCHEMBL20754493 | 0.80 | ADORA2A (0.38) | ADORA3ADORA1ADORA2AADORA2BCYP2C19 | |
| SCHEMBL15255196 | 0.79 | SLC29A1 (0.41) | ADORA3ADORA1ADORA2AADORA2BCYP2C19 | |
| SCHEMBL20611183 | 0.79 | STING1 (0.36) | ADORA3ADORA1ADORA2BSLC29A1HINT1 | |
| SCHEMBL17378467 | 0.77 | ADORA2A (0.35) | ADORA3ADORA1ADORA2AADORA2BCYP2C19 | |
| SCHEMBL20611193 | 0.77 | ADORA3 (0.54) | ADORA3HINT1 | |
| SCHEMBL17403983 | 0.77 | ADORA3 (0.38) | ADORA3ADORA1ADORA2AADORA2BCYP2C19 | |
| SCHEMBL23584291 | 0.77 | ADORA2A (0.45) | ADORA3ADORA1ADORA2AADORA2BCYP2C19 | |
| SCHEMBL10266182 | 0.77 | ADORA2A (0.45) | ADORA3ADORA1ADORA2AADORA2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160476-B1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTION | JANSSEN BIOPHARMA INC (US) | 2020-09-30 | — | — | EP | disclosed |