Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.36 |
| ▸ | HINT1 | P49773 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23171036 | 0.80 | ADORA3 (0.50) | HPGDHINT1STING1NT5EADORA3 | |
| SCHEMBL18672166 | 0.80 | HPGD (0.36) | HPGDIMPDH2IMPDH1HINT1TAS1R3 | |
| SCHEMBL16144362 | 0.77 | HPGD (0.44) | HPGDIMPDH2IMPDH1HINT1TAS1R3 | |
| SCHEMBL16144363 | 0.75 | HPGD (0.41) | HPGDIMPDH2IMPDH1HINT1TAS1R3 | |
| SCHEMBL15070825 | 0.74 | HPGD (0.41) | HPGDIMPDH2IMPDH1HINT1TAS1R3 | |
| SCHEMBL15837260 | 0.74 | ADORA3 (0.37) | HPGDIMPDH2IMPDH1HINT1TAS1R3 | |
| SCHEMBL18022452 | 0.73 | HPGD (0.39) | HPGDIMPDH2IMPDH1HINT1TAS1R3 | |
| SCHEMBL18022450 | 0.73 | HPGD (0.42) | HPGDIMPDH2IMPDH1HINT1TAS1R3 | |
| SCHEMBL15837294 | 0.73 | ADORA3 (0.36) | HPGDIMPDH2IMPDH1HINT1NT5E | |
| SCHEMBL17357693 | 0.72 | HPGD (0.46) | HPGDIMPDH2PAX8ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160476-B1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTION | JANSSEN BIOPHARMA INC (US) | 2020-09-30 | — | — | EP | disclosed |