Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 11/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167576 | 0.88 | MET (0.37) | HDAC3ARMETDYRK1ANPC1 | |
| SCHEMBL22475688 | 0.87 | HDAC3 (0.42) | HDAC3ARMETPDK1 | |
| SCHEMBL22475836 | 0.85 | MET (0.35) | HDAC3ARMETNPC1 | |
| SCHEMBL21167331 | 0.84 | SYK (0.37) | HDAC3METDYRK1APDE10A | |
| SCHEMBL21167377 | 0.83 | MAT2A (0.39) | HDAC3METDYRK1APDE10A | |
| SCHEMBL22475938 | 0.82 | MET (0.48) | HDAC3METDYRK1ANPC1POLB | |
| SCHEMBL22475827 | 0.81 | MET (0.56) | HDAC3METCDKL5 | |
| SCHEMBL23127972 | 0.80 | PIK3CD (0.42) | HDAC3METPDK1PDE10A | |
| SCHEMBL22475826 | 0.78 | MET (0.52) | METPDE10A | |
| SCHEMBL21171666 | 0.78 | CNR2 (0.46) | METPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |