Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22476545 | 0.89 | PREP (0.36) | PREPCHRNB4CHRNA3MTNR1BACE | |
| SCHEMBL18683750 | 0.80 | NPC1 (0.41) | PREPMEN1KMT2ATAAR1GAA | |
| SCHEMBL23154537 | 0.78 | ACE (0.46) | ACEKMT2AGAAMAPK1 | |
| SCHEMBL25949990 | 0.78 | ACE (0.46) | ACEKMT2AGAAMAPK1 | |
| SCHEMBL18688556 | 0.78 | ACE (0.46) | ACEKMT2AGAAMAPK1 | |
| SCHEMBL21699268 | 0.78 | CYP2C9 (0.49) | CYP2D6GAAATML3MBTL1TSHR | |
| SCHEMBL21335916 | 0.78 | PREP (0.46) | PREPACETSHR | |
| SCHEMBL21699258 | 0.78 | CYP2C9 (0.49) | CYP2D6GAAATML3MBTL1TSHR | |
| SCHEMBL22476440 | 0.77 | F2 (0.38) | PREPACEMEN1KMT2AGAA | |
| SCHEMBL19443278 | 0.77 | MMP1 (0.44) | ACEGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303366-B1 | DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF | NEWBIO THERAPEUTICS INC (CN) | 2020-09-30 | — | — | EP | disclosed |