SCHEMBL224770

SCHEMBL224770

c1ccc(-c2nc[nH]c2-c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 1.00
CYP3A4 P08684 1/20 1.00
MAPT P10636 1/20 1.00
IDO1 P14902 4/20 0.68
MAPK14 Q16539 5/20 0.55
MAPK13 O15264 1/20 0.55
RAF1 P04049 1/20 0.55
MAPK9 P45984 1/20 0.55
MAPK12 P53778 1/20 0.55
MAPK11 Q15759 1/20 0.55
ALDH1A1 P00352 4/20 0.47
POLB P06746 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
ADORA3 P0DMS8 1/20 0.46
ADORA2A P29274 1/20 0.46
ADORA1 P30542 1/20 0.46
HPGD P15428 4/20 0.44
GAA P10253 2/20 0.44
HSD17B10 Q99714 2/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL31020961 0.98 KDM4E (0.96) KDM4ECYP3A4MAPTIDO1MAPK14
SCHEMBL1387736 0.90 KDM4E (0.81) KDM4ECYP3A4MAPTIDO1MAPK14
SCHEMBL4882839 0.90 KDM4E (0.81) KDM4ECYP3A4MAPTIDO1MAPK14
Phenol SCHEMBL27639361 0.90 MAPT (0.81) KDM4ECYP3A4MAPTIDO1MAPK14
SCHEMBL10397990 0.89 KDM4E (0.79) KDM4ECYP3A4MAPTIDO1MAPK14
SCHEMBL10892821 0.86 KDM4E (0.73) KDM4ECYP3A4MAPTIDO1MAPK14
Imidazole SCHEMBL9109434 0.84 CYP3A4 (0.71) KDM4ECYP3A4MAPTIDO1MAPK14
2-Phenylimidazole SCHEMBL9568277 0.84 KDM4E (0.71) KDM4ECYP3A4MAPTIDO1MAPK14
SCHEMBL11052460 0.84 CYP3A4 (0.71) KDM4ECYP3A4MAPTIDO1MAPK14
SCHEMBL5962614 0.84 KDM4E (0.71) KDM4ECYP3A4MAPTIDO1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1236 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12637541-B2 Alkylene oxide polymerization using aluminum compounds and cyclic amidines DOW GLOBAL TECHNOLOGIES LLC (US) 2026-05-26 US claimed
EP-4321541-B1 RESIN COMPOSITION, RESIN SHEET, MULTILAYER PRINTED WIRING BOARD AND SEMICONDUCTOR DEVICE MITSUBISHI GAS CHEMICAL CO (JP) 2025-08-06 EP claimed
CN-119613715-B Cationic organic polymer and preparation method and application thereof 兰州大学 2025-04-25 CN claimed
CN-119661817-A Synthetic method of liquid crystal polyarylester and application of high-boiling-point imidazole catalyst in synthesis of liquid crystal polyarylester 浙江聚领新材料有限公司 2025-03-21 CN claimed
CN-119613715-A Cationic organic polymer and preparation method and application thereof 兰州大学 2025-03-14 CN claimed
CN-119510627-A Analysis method and application of selective enrichment of important biomarkers related to oxidative stress 上海交通大学 2025-02-25 CN claimed
CN-118813261-A Silicon nitride etching solution suitable for deep trench etching 湖北兴福电子材料股份有限公司 2024-10-22 CN claimed
US-11965110-B2 Polyimide varnish composition for flexible substrate and polyimide film using same NEXFLEX CO., LTD. (KR) 2024-04-23 US claimed
CN-117567973-B High Tg underfill and preparation method thereof 深圳先进电子材料国际创新研究院 2024-04-09 CN claimed
CN-117567973-A High Tg underfill and preparation method thereof 深圳先进电子材料国际创新研究院 2024-02-20 CN claimed
US-4889911-A ESTERIFICATION, ESTER INTERCHANGE; CATALYSIS WITH HETEROCYCLIC NITROGEN COMPOUND BAYER AKTIENGESELLSCHAFT (DE) 1989-12-26 US claimed
EP-0303931-A2 Process for the fabrication of thermotropic, wholly aromatic polyesters and polyestercarbonates BAYER AG (DE) 1989-02-22 EP claimed
US-4662905-A REACTION PRODUCT OF COPPER SALT AND AN IMIDAZOLE, PYRAZOLE, TRIAZOLE, OR TETRAZOLE Itaru Todoriki, Director of Agency of Industrial Science and Technology (JP) 1987-05-05 US claimed
EP-0206030-A2 Photocurable composition SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1986-12-30 EP claimed
EP-0053040-B1 PHOTOSENSITIVE ELEMENTS, COLOUR IMAGE TRANSFER FILM UNITS AND IMAGE DYE PROVIDING COMPOUNDS FOR USE THEREIN EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1986-02-12 EP claimed
EP-0053037-B1 PHOTOSENSITIVE ELEMENTS, COLOUR IMAGE TRANSFER FILM UNITS AND IMAGE DYE PROVIDING COMPOUNDS FOR USE THEREIN EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-12-18 EP claimed
US-4418143-A Color photographic recording material AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) 1983-11-29 US claimed
EP-0053037-A2 Photosensitive elements, colour image transfer film units and image dye providing compounds for use therein EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-06-02 EP claimed
EP-0053040-A2 Photosensitive elements, colour image transfer film units and image dye providing compounds for use therein EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-06-02 EP claimed
US-3997552-A HERBICIDE BAYER AKTIENGESELLSCHAFT (DT) 1976-12-14 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12637541-B2 Alkylene oxide polymerization using aluminum compounds and cyclic amidines MLST8, PFAS, SQLE KDM4E 2064/4885CYP3A4 1468/4885MAPT 3831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.