Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22482002 | 0.92 | KMT2A (0.65) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| Doxofylline SCHEMBL5964475 | 0.84 | KMT2A (1.00) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| Doxofylline SCHEMBL37963 | 0.84 | KMT2A (1.00) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| Doxofylline SCHEMBL27924903 | 0.83 | KMT2A (0.97) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| Doxofylline SCHEMBL27934328 | 0.83 | KMT2A (0.97) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| Doxofylline SCHEMBL27949428 | 0.83 | KMT2A (0.97) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| Doxofylline SCHEMBL27934338 | 0.83 | KMT2A (0.97) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| SCHEMBL9293404 | 0.77 | KMT2A (0.74) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 | |
| SCHEMBL16120984 | 0.77 | ADORA2B (0.81) | ADORA2BLMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL18256126 | 0.77 | KMT2A (0.69) | KMT2AADORA2BLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020194223-A1 | DOXOPHYLLINE DERIVATIVES | ABC FARMACEUTICI S.P.A. (IT) | 2020-10-01 | — | — | WO | disclosed |