Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 4/20 | 0.33 |
| ▸ | ERN1 | O75460 | 7/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22465864 | 0.82 | SNCA (0.38) | SNCAERN1MAPTLMNATOP1 | |
| SCHEMBL22482252 | 0.79 | LMNA (0.36) | SNCAERN1MAPTLMNATOP1 | |
| SCHEMBL22465977 | 0.70 | TOP1 (0.41) | SNCAERN1MAPTLMNATOP1 | |
| SCHEMBL29378214 | 0.70 | TOP1 (0.41) | SNCAERN1MAPTLMNATOP1 | |
| SCHEMBL29381898 | 0.69 | ERN1 (0.50) | SNCAERN1TOP1TOP2ATOP2B | |
| SCHEMBL22466044 | 0.69 | ERN1 (0.50) | SNCAERN1TOP1TOP2ATOP2B | |
| SCHEMBL22482236 | 0.68 | SNCA (0.39) | SNCAERN1MAPTLMNATOP1 | |
| SCHEMBL22485146 | 0.68 | TOP1 (0.43) | SNCAERN1TOP1TOP2ATOP2B | |
| SCHEMBL22465871 | 0.68 | TOP1 (0.41) | SNCAERN1MAPTLMNATOP1 | |
| SCHEMBL22484858 | 0.67 | TOP1 (0.43) | SNCAERN1MAPTTOP1TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198368-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING | NEUROPORE THERAPIES, INC. (US) | 2020-10-01 | — | — | WO | disclosed |