Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 14/20 | 0.80 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24513595 | 0.89 | FOXO1 (1.00) | FOXO1PDE10AACHEPDPK1SMN1; SMN2 | |
| SCHEMBL22489139 | 0.85 | FOXO1 (0.77) | FOXO1PDE10AACHEPDPK1 | |
| SCHEMBL22489135 | 0.85 | FOXO1 (0.77) | FOXO1PDE10AACHEPDPK1SMN1; SMN2 | |
| SCHEMBL22488741 | 0.78 | ACHE (0.81) | FOXO1PDE10AACHE | |
| SCHEMBL15705185 | 0.78 | PDPK1 (0.52) | FOXO1PDPK1SMN1; SMN2 | |
| SCHEMBL24512908 | 0.78 | FOXO1 (0.80) | FOXO1PDE10AACHE | |
| SCHEMBL22489136 | 0.77 | FOXO1 (0.74) | FOXO1PDE10AACHESMN1; SMN2 | |
| SCHEMBL25429204 | 0.77 | FOXO1 (0.64) | FOXO1PDE10AACHE | |
| SCHEMBL30754034 | 0.77 | FOXO1 (0.64) | FOXO1PDE10AACHE | |
| SCHEMBL25428325 | 0.75 | FOXO1 (0.70) | FOXO1PDE10AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198351-A1 | SELECTIVE FOXO INHIBITORS FOR TREATMENT OF DIABETES AND OTHER DISORDERS RELATED TO IMPAIRED PANCREATIC FUNCTION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-10-01 | — | — | WO | disclosed |