Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 1/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067023 | 0.83 | MMP8 (0.42) | ALDH1A1TSHRCYP4F2CYP4A11PKM | |
| SCHEMBL12574804 | 0.81 | STING1 (0.40) | TET2STING1ALDH1A1TSHRCYP4F2 | |
| SCHEMBL2770601 | 0.81 | MEN1 (0.43) | ALDH1A1TSHRCYP4F2CYP4A11PKM | |
| SCHEMBL12130916 | 0.80 | ALDH1A1 (0.45) | TET2ALDH1A1TSHRCYP4F2CYP4A11 | |
| SCHEMBL22490385 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRCYP4F2CYP4A11PKM | |
| SCHEMBL7066945 | 0.78 | MEN1 (0.41) | ALDH1A1TSHRCYP4F2CYP4A11PKM | |
| SCHEMBL22490383 | 0.77 | POLB (0.52) | TET2ALDH1A1TSHRMAPTNPSR1 | |
| SCHEMBL6667303 | 0.76 | HMGCR (0.46) | STING1ALDH1A1TSHRCYP4F2CYP4A11 | |
| SCHEMBL3280616 | 0.76 | GAA (0.46) | STING1ALDH1A1CYP4F2CYP4A11PKM | |
| SCHEMBL4893886 | 0.76 | ALDH1A1 (0.36) | STING1ALDH1A1TSHRPKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3716956-B1 | ANTITUMOR TET2 MODULATING COMPOUNDS | CLEVELAND CLINIC FOUND (US) | 2024-06-26 | — | — | EP | disclosed |
| US-20200306221-A1 | ANTITUMOR TET2 MODULATING COMPOUNDS | THE CLEVELAND CLINIC FOUNDATION | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200306221-A1 | ANTITUMOR TET2 MODULATING COMPOUNDS | TET2, TET1, TET3 | TET2 1/4885STING1 194/4885ALDH1A1 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.