⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26151369 | 0.72 | TDP1 (0.41) | — | |
| SCHEMBL18171007 | 0.72 | KDM4E (0.43) | — | |
| SCHEMBL20203202 | 0.68 | MEN1 (0.37) | — | |
| SCHEMBL21393376 | 0.68 | KDM4E (0.35) | — | |
| SCHEMBL20187436 | 0.68 | ALDH1A1 (0.50) | — | |
| SCHEMBL29526625 | 0.68 | ALDH1A1 (0.50) | — | |
| SCHEMBL27365834 | 0.68 | — | — | |
| SCHEMBL14494901 | 0.66 | — | — | |
| SCHEMBL541849 | 0.65 | — | — | |
| SCHEMBL12915143 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11242361-B2 | Proteasome activity enhancing compounds | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2022-02-08 | — | — | US | disclosed |
| US-20200308198-A1 | PROTEASOME ACTIVITY ENHANCING COMPOUNDS | PROTEOSTASIS THERAPEUTICS, INC. | 2020-10-01 | — | — | US | disclosed |