Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2721703 | 0.87 | GAA (0.41) | KDM4EPKMALDH1A1LMNAMAPT | |
| SCHEMBL855352 | 0.84 | DYRK1A (0.37) | KDM4EPKMALDH1A1LMNAMAPT | |
| SCHEMBL5103470 | 0.80 | DYRK1A (0.39) | KDM4EPKMALDH1A1LMNAMAPT | |
| SCHEMBL2971825 | 0.80 | DYRK1A (0.39) | KDM4EPKMALDH1A1LMNAMAPT | |
| SCHEMBL7835407 | 0.80 | TDP1 (0.39) | KDM4EPKMALDH1A1LMNAMAPT | |
| SCHEMBL13607868 | 0.80 | KMT2A (0.46) | ALDH1A1MAPTKMT2AABL1RET | |
| SCHEMBL13607882 | 0.79 | SMN1; SMN2 (0.38) | KDM4EPKMALDH1A1LMNAMAPT | |
| SCHEMBL13607778 | 0.79 | RAB9A (0.51) | ALDH1A1LMNAMAPTNTRK1GSK3B | |
| SCHEMBL27709833 | 0.79 | ABL1 (0.32) | KDM4EPKMALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL2972038 | 0.79 | BDKRB2 (0.35) | KDM4EPKMALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198053-A1 | 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-10-01 | — | — | WO | disclosed |