SCHEMBL22490923

SCHEMBL22490923

COc1cc(OCc2ccccc2)cc(C)c1C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
MRGPRX4 Q96LA9 6/20 0.50
RXRA P19793 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.48
NR4A2 P43354 2/20 0.48
NR4A1 P22736 1/20 0.48
NR4A3 Q92570 1/20 0.48
MAOB P27338 1/20 0.48
RAB9A P51151 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
HPGD P15428 1/20 0.47
TP53 P04637 1/20 0.47
PKM P14618 1/20 0.47
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
P4HTM Q9NXG6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1842000 0.92 MEN1 (0.56) MEN1KMT2AMRGPRX4RXRANR4A2
SCHEMBL31643571 0.91 MEN1 (0.59) MEN1KMT2AMRGPRX4RXRAL3MBTL1
SCHEMBL31638824 0.89 MRGPRX4 (0.48) MEN1KMT2AMRGPRX4RXRAL3MBTL1
SCHEMBL31659387 0.89 HPGD (0.49) MEN1KMT2AL3MBTL1MAOBRAB9A
SCHEMBL597702 0.88 MEN1 (0.63) MEN1KMT2AMRGPRX4RXRANR4A2
SCHEMBL31643437 0.88 MEN1 (0.52) MEN1KMT2AMRGPRX4RXRAL3MBTL1
SCHEMBL31643884 0.86 IDO1 (0.47) MEN1KMT2AMRGPRX4HPGDGSK3B
SCHEMBL31643556 0.85 MEN1 (0.50) MEN1KMT2AMRGPRX4RXRAL3MBTL1
SCHEMBL31644137 0.85 MEN1 (0.50) MEN1KMT2AMRGPRX4RXRAL3MBTL1
SCHEMBL4851469 0.84 MEN1 (0.49) MEN1KMT2AMRGPRX4NR4A2NR4A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250228811-A1 Triester Compounds And Methods Of Use Thereof LIFEMINE THERAPEUTICS, INC. 2025-07-17 US disclosed
WO-2025137071-A2 TRIESTER COMPOUNDS AND METHODS OF USE THEREOF LIFEMINE THERAPEUTICS, INC. (US) 2025-06-26 WO disclosed
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
EP-3717463-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN Sanofi (FR) 2020-10-07 EP disclosed
CN-111433193-A Novel conjugates of agents and moieties capable of binding to glucose sensing proteins 赛诺菲 2020-07-17 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 MEN1 1749/4885KMT2A 4555/4885MRGPRX4 87/4885
US-20250228811-A1 Triester Compounds And Methods Of Use Thereof CYP46A1, CYP17A1, CYP27A1 MEN1 2994/4885KMT2A 2874/4885MRGPRX4 781/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.