Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 12/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 6/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6834015 | 0.90 | SHMT1 (0.49) | SHMT1SHMT2MAPTLMNAMMP3 | |
| SCHEMBL5870566 | 0.84 | SHMT1 (0.60) | SHMT1SHMT2MAPTPRKD3PRKCG | |
| SCHEMBL5869868 | 0.84 | SHMT1 (0.60) | SHMT1SHMT2MAPTPRKD3PRKCG | |
| SCHEMBL5870570 | 0.84 | SHMT1 (0.60) | SHMT1SHMT2MAPTPRKD3PRKCG | |
| SCHEMBL8249164 | 0.74 | KDM4E (0.50) | SHMT1SHMT2MAPTLMNAHPGD | |
| SCHEMBL1690993 | 0.74 | KDM4E (0.50) | SHMT1SHMT2MAPTLMNAHPGD | |
| SCHEMBL6927461 | 0.73 | ACE2 (0.48) | SHMT1SHMT2TLR7 | |
| SCHEMBL5869952 | 0.73 | ACE2 (0.48) | SHMT1SHMT2TLR7 | |
| SCHEMBL5869503 | 0.73 | ACE2 (0.48) | SHMT1SHMT2TLR7 | |
| SCHEMBL5869959 | 0.73 | ACE2 (0.48) | SHMT1SHMT2TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717077-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (DE) | 2020-10-07 | — | — | EP | disclosed |