Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 12/20 | 0.60 |
| ▸ | SHMT2 | P34897 | 8/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869868 | 1.00 | SHMT1 (0.60) | SHMT1SHMT2ACE2ACEPRKD3 | |
| SCHEMBL5870570 | 1.00 | SHMT1 (0.60) | SHMT1SHMT2ACE2ACEPRKD3 | |
| SCHEMBL21560223 | 0.85 | SHMT1 (0.79) | SHMT1SHMT2 | |
| SCHEMBL21560079 | 0.85 | SHMT1 (0.79) | SHMT1SHMT2 | |
| SCHEMBL5869503 | 0.85 | ACE2 (0.48) | SHMT1SHMT2ACE2ACETLR7 | |
| SCHEMBL6927461 | 0.85 | ACE2 (0.48) | SHMT1SHMT2ACE2ACETLR7 | |
| SCHEMBL5869959 | 0.85 | ACE2 (0.48) | SHMT1SHMT2ACE2ACETLR7 | |
| SCHEMBL5869952 | 0.85 | ACE2 (0.48) | SHMT1SHMT2ACE2ACETLR7 | |
| SCHEMBL6834015 | 0.84 | SHMT1 (0.49) | SHMT1SHMT2MAPT | |
| SCHEMBL22491272 | 0.84 | SHMT1 (0.48) | SHMT1SHMT2PRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |