Sugi Predict

Sugi Predict / Compounds / SCHEMBL22492040

SCHEMBL22492040

SCHEMBL22492040

O=C(O)[C@@H]1CCC(F)(F)C[C@H]1c1ccncc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNQ3 O43525 4/20 0.41
▸ KCNQ2 O43526 4/20 0.41
▸ KCNQ4 P56696 3/20 0.41
▸ KCNQ5 Q9NR82 3/20 0.41
▸ POLB P06746 1/20 0.40
▸ TSHR P16473 1/20 0.40
▸ ALDH1A1 P00352 2/20 0.37
▸ NAMPT P43490 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ HSD17B10 Q99714 2/20 0.36
▸ MAPT P10636 1/20 0.36
▸ DDB1 Q16531 1/20 0.35
▸ CRBN Q96SW2 1/20 0.35
▸ CTSK P43235 2/20 0.33
▸ SLC6A12 P48065 1/20 0.33
▸ SLC6A11 P48066 1/20 0.33
▸ KDM1A O60341 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22492037 1.00 KCNQ3 (0.41) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL22492042 1.00 KCNQ3 (0.41) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL22492099 0.86 KCNQ3 (0.53) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL22492105 0.86 KCNQ3 (0.53) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL22492104 0.86 KCNQ3 (0.53) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL22492067 0.77 POLB (0.38) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL21611532 0.77 KCNQ3 (0.38) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL21611533 0.77 KCNQ3 (0.38) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL21611529 0.77 KCNQ3 (0.38) KCNQ3KCNQ2KCNQ4KCNQ5POLB
SCHEMBL22492068 0.77 POLB (0.38) KCNQ3KCNQ2KCNQ4KCNQ5POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11332472-B2 Substituted piperidines as inhibitors of ubiquitin specific protease 7 LES LABORATOIRES SERVIER (FR) 2022-05-17 — — US disclosed
US-20200407363-A1 NEW PIPERIDINYL DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 LES LABORATOIRES SERVIER (FR) 2020-12-31 — — US disclosed
EP-3717482-A1 NEW PIPERIDINYL DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 Les Laboratoires Servier SAS (FR) 2020-10-07 — — EP disclosed
CN-111542524-A Novel piperidinyl derivatives as inhibitors of ubiquitin-specific protease 7 法国施维雅药厂 2020-08-14 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11332472-B2 Substituted piperidines as inhibitors of ubiquitin specific protease 7 USP7, PSMA7, PSMB7 KCNQ3 4231/4885KCNQ2 3921/4885KCNQ4 4466/4885
US-20200407363-A1 NEW PIPERIDINYL DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 PSMB7, PSMA7, USP7 KCNQ3 4378/4885KCNQ2 3943/4885KCNQ4 4511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.