Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22492845 | 0.85 | CKS1B (0.45) | CA12CA1CA2CA9BRD4 | |
| SCHEMBL22510566 | 0.80 | GRM5 (0.40) | GRM5PDE2APTGS2 | |
| SCHEMBL21601467 | 0.77 | CA12 (0.69) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL5150633 | 0.71 | MALT1 (0.48) | CA12CA1CA2CA9MTNR1A | |
| SCHEMBL38661180 | 0.71 | CA12 (0.45) | CA12CA1CA2CA9DYRK1A | |
| SCHEMBL8380141 | 0.71 | NPC1 (0.51) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL26926861 | 0.70 | CA12 (0.50) | CA12CA1CA2CA9DYRK1A | |
| SCHEMBL14504739 | 0.70 | RPA1 (0.60) | CA12CA1CA2CA9 | |
| SCHEMBL5149014 | 0.70 | CA12 (0.46) | CA12CA1CA2CA9SUCNR1 | |
| SCHEMBL5148958 | 0.70 | PTGS2 (0.49) | CA12CA1CA2CA9PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11457628-B2 | Substituted pyrimidine compound and preparation method and use thereof | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2022-10-04 | — | — | US | disclosed |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2021-01-21 | — | — | US | disclosed |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) | 2021-01-21 | — | — | US | disclosed |
| EP-3719015-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2020-10-07 | — | — | EP | disclosed |
| EP-3719015-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2020-10-07 | — | — | EP | disclosed |
| CN-111263757-A | Substituted pyrimidine compound and preparation method and application thereof | 沈阳中化农药化工研发有限公司 | 2020-06-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11457628-B2 | Substituted pyrimidine compound and preparation method and use thereof | GART, BROX, APRT | CA12 3245/4885CA1 993/4885CA2 2578/4885 |
| US-20210015100-A1 | SUBSTITUTED PYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF | GART, BROX, APRT | CA12 3245/4885CA1 993/4885CA2 2578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.