⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30995309 | 0.69 | — | — | |
| SCHEMBL20525064 | 0.69 | — | — | |
| SCHEMBL22401553 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL25423890 | 0.57 | ADORA3 (0.30) | — | |
| SCHEMBL17936973 | 0.56 | — | — | |
| SCHEMBL29599549 | 0.56 | PDPK1 (0.31) | — | |
| SCHEMBL19253533 | 0.55 | GABRG2 (0.31) | — | |
| SCHEMBL15473978 | 0.54 | — | — | |
| SCHEMBL20525075 | 0.54 | CRBN (0.36) | — | |
| SCHEMBL28963841 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12150941-B2 | Process for preparing substituted pyrazolo[1,5-a]pyrazines | Sumitomo Pharma Co., Ltd. (JP) | 2024-11-26 | — | — | US | disclosed |
| EP-3719023-B1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF | SUMITOMO PHARMA CO LTD (JP) | 2024-10-16 | — | — | EP | disclosed |
| CN-116744926-A | Compounds as inhibitors of casein kinase | 北京原基华毅生物科技有限公司 | 2023-09-12 | — | — | CN | disclosed |
| US-20230210850-A1 | PROCESS FOR PREPARING SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINES | Sumitomo Pharma Co., Ltd. (JP) | 2023-07-06 | — | — | US | disclosed |
| CN-111601811-B | 6, 7-dihydropyrazolo [1,5-a ] pyrazinone derivatives and medical uses thereof | 住友制药株式会社 | 2023-05-05 | — | — | CN | disclosed |
| CN-111601811-B | 6, 7-dihydropyrazolo [1,5-a ] pyrazinone derivatives and medical uses thereof | 住友制药株式会社 | 2023-05-05 | — | — | CN | disclosed |
| US-11633395-B2 | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor | Sumitomo Pharma Co., Ltd. (JP) | 2023-04-25 | — | — | US | disclosed |
| US-10953008-B2 | Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-03-23 | — | — | US | disclosed |
| US-20210030754-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-02-04 | — | — | US | disclosed |
| US-20200345729-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-11-05 | — | — | US | disclosed |
| EP-3719023-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL APPLICATION THEREOF | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2020-10-07 | — | — | EP | disclosed |
| CN-111601811-A | 6, 7-dihydropyrazolo [1,5-a ] pyrazinone derivatives and their pharmaceutical use | 大日本住友制药株式会社 | 2020-08-28 | — | — | CN | disclosed |
| CN-111601811-A | 6, 7-dihydropyrazolo [1,5-a ] pyrazinone derivatives and their pharmaceutical use | 大日本住友制药株式会社 | 2020-08-28 | — | — | CN | disclosed |