Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.51 |
| ▸ | EGLN2 | Q96KS0 | 12/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22588812 | 0.99 | EGLN1 (0.53) | EGLN1EGLN2PTGS2SCN9AGABRA1 | |
| SCHEMBL6060051 | 0.90 | EGLN1 (0.48) | EGLN1EGLN2THRATHRBCYP1A2 | |
| SCHEMBL6060946 | 0.89 | EGLN1 (0.49) | EGLN1EGLN2PTGS2SCN9AGABRA1 | |
| SCHEMBL15268696 | 0.89 | EGLN1 (0.55) | EGLN1EGLN2THRATHRB | |
| SCHEMBL523263 | 0.86 | EGLN1 (0.64) | EGLN1EGLN2PTGS2 | |
| SCHEMBL23929416 | 0.86 | EGLN1 (0.57) | EGLN1EGLN2 | |
| SCHEMBL14942062 | 0.84 | EGLN1 (0.55) | EGLN1EGLN2 | |
| SCHEMBL6060086 | 0.82 | EGLN2 (0.48) | EGLN1EGLN2PTGS2GABRA1GABRG2 | |
| SCHEMBL6060534 | 0.81 | POLB (0.40) | EGLN1EGLN2PTGS2GABRA1GABRG2 | |
| SCHEMBL6059991 | 0.81 | PPARG (0.40) | EGLN1EGLN2GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717456-A1 | PROCESS FOR THE PREPARATION OF ROXADUSTAT AND ITS INTERMEDIATES | Dr. Reddy's Laboratories Limited (IN) | 2020-10-07 | — | — | EP | disclosed |