Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 12/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6060364 | 0.90 | EGLN1 (0.52) | EGLN1EGLN2 | |
| SCHEMBL22493050 | 0.89 | EGLN1 (0.51) | EGLN1EGLN2PTGS2GABRA1GABRG2 | |
| Hydrochloric Acid SCHEMBL22588812 | 0.88 | EGLN1 (0.53) | EGLN1EGLN2PTGS2GABRA1GABRG2 | |
| SCHEMBL523263 | 0.84 | EGLN1 (0.64) | EGLN1EGLN2PTGS2 | |
| SCHEMBL3914540 | 0.84 | EGLN1 (0.70) | EGLN1EGLN2 | |
| SCHEMBL6059798 | 0.83 | EGLN1 (0.48) | EGLN1EGLN2GABRA1GABRG2GABRB3 | |
| SCHEMBL5315433 | 0.83 | EGLN1 (0.50) | EGLN1EGLN2 | |
| SCHEMBL6060051 | 0.80 | EGLN1 (0.48) | EGLN1EGLN2ALDH1A1MAPTHPGD | |
| SCHEMBL6059995 | 0.80 | EGLN1 (0.56) | EGLN1EGLN2 | |
| SCHEMBL6059867 | 0.79 | EGLN1 (0.52) | EGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |