Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.66 |
| ▸ | MAP4K3 | Q8IVH8 | 4/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.66 |
| ▸ | PLK4 | O00444 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.66 |
| ▸ | INSR | P06213 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | FES | P07332 | 2/20 | 0.66 |
| ▸ | CSF1R | P07333 | 2/20 | 0.66 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | IGF1R | P08069 | 2/20 | 0.66 |
| ▸ | ROS1 | P08922 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
| ▸ | FER | P16591 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22493294 | 1.00 | MET (0.66) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL19826795 | 0.92 | MET (0.69) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL19821490 | 0.91 | MET (0.71) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL18651450 | 0.90 | MET (0.67) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL18651458 | 0.90 | MET (0.67) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL17446128 | 0.90 | MET (0.67) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL18079398 | 0.90 | MET (0.67) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL17445328 | 0.90 | MET (0.67) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL20086734 | 0.90 | MET (0.67) | METALKMAP4K3JAK2PLK4 | |
| SCHEMBL18561630 | 0.90 | MET (0.70) | METALKMAP4K3JAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11771709-B2 | ALK protein degradation agent and anti-tumor application thereof | SHANGHAITECH UNIVERSITY (CN) | 2023-10-03 | — | — | US | disclosed |
| US-20200306273-A1 | ALK PROTEIN DEGRADATION AGENT AND ANTI-TUMOR APPLICATION THEREOF | SHANGHAITECH UNIVERSITY (CN) | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200306273-A1 | ALK PROTEIN DEGRADATION AGENT AND ANTI-TUMOR APPLICATION THEREOF | ADRM1, VHL, MDM2 | MET 71/4885ALK 5/4885MAP4K3 1077/4885 |
| US-11771709-B2 | ALK protein degradation agent and anti-tumor application thereof | ADRM1, VHL, MDM2 | MET 71/4885ALK 5/4885MAP4K3 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.