Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.56 |
| ▸ | RARA | P10276 | 2/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1533783 | 0.85 | RARB (0.47) | RARBRARARARGHTR2AS1PR1 | |
| SCHEMBL1533759 | 0.82 | RARB (0.44) | RARBRARARARGHTR2AKDM4E | |
| SCHEMBL13310852 | 0.82 | RARB (0.68) | RARBRARARARGHTR2AKDM4E | |
| SCHEMBL9563730 | 0.82 | RARB (0.68) | RARBRARARARGHTR2AKDM4E | |
| SCHEMBL11015800 | 0.82 | HSD17B10 (0.51) | RARBRARARARGHTR2ATNNC1 | |
| SCHEMBL26481762 | 0.82 | RARB (0.49) | RARBRARARARGHTR2AKDM4E | |
| SCHEMBL10532811 | 0.81 | RARB (0.67) | RARBRARARARGHTR2AKDM4E | |
| SCHEMBL1533776 | 0.81 | RARB (0.42) | RARBRARARARGS1PR1S1PR3 | |
| SCHEMBL26481759 | 0.81 | RARB (0.48) | RARBRARARARGHTR2AKDM4E | |
| SCHEMBL10986616 | 0.81 | RARB (0.70) | RARBRARARARGHTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107011920-B | Liquid-crystalline medium comprising thiophene derivatives | 默克专利股份有限公司 | 2021-06-22 | — | — | CN | disclosed |
| EP-2598604-B1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-11-25 | — | — | EP | disclosed |
| EP-2598604-B1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-11-25 | — | — | EP | disclosed |
| US-8906261-B2 | Liquid crystal medium containing thiophene derivatives | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| US-8906261-B2 | Liquid crystal medium containing thiophene derivatives | MERCK PATENT GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| US-8486297-B2 | Thiophene derivatives, and LC media comprising same | MERCK PATENT GMBH (DE) | 2013-07-16 | — | — | US | disclosed |
| US-8486297-B2 | Thiophene derivatives, and LC media comprising same | MERCK PATENT GMBH (DE) | 2013-07-16 | — | — | US | disclosed |
| EP-2598604-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | Merck Patent GmbH (DE) | 2013-06-05 | — | — | EP | disclosed |
| US-20130119312-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-05-16 | — | — | US | disclosed |
| US-20130119312-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-05-16 | — | — | US | disclosed |
| WO-2012013281-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
| WO-2012013281-A1 | LIQUID CRYSTAL MEDIUM CONTAINING THIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-02-02 | — | — | WO | disclosed |
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-05 | — | — | US | disclosed |
| EP-2398787-A1 | THIOPHENE DERIVATES AND LIQUID CRYSTAL MEDIA COMPRISING THE SAME | Merck Patent GmbH (DE) | 2011-12-28 | — | — | EP | disclosed |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-03 | — | — | US | disclosed |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-03 | — | — | US | disclosed |
| EP-2265692-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA CONTAINING THE SAME | Merck Patent GmbH (DE) | 2010-12-29 | — | — | EP | disclosed |
| WO-2010099853-A1 | THIOPHENE DERIVATES AND LIQUID CRYSTAL MEDIA COMPRISING THE SAME | MERCK PATENT GMBH (DE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009129915-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA CONTAINING THE SAME | MERCK PATENT GMBH (DE) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | TEC, TPMT, TST | RARB 3907/4885RARA 3956/4885RARG 4205/4885 |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | TPMT, TEC, LCT | RARB 3984/4885RARA 4056/4885RARG 4297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.