Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 20/20 | 1.00 |
| ▸ | PSEN1 | P49768 | 12/20 | 0.75 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.75 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.75 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.75 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.75 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22494456 | 1.00 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494463 | 0.92 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494484 | 0.92 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494466 | 0.89 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494451 | 0.89 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22504260 | 0.88 | APP (0.83) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494454 | 0.86 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494459 | 0.86 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494483 | 0.85 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22494478 | 0.85 | APP (1.00) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728262-B1 | TRIAZOLO-AZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-03-15 | — | — | EP | claimed |
| US-11440915-B2 | Triazolo-azepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2022-09-13 | — | — | US | claimed |
| US-20200317681-A1 | TRIAZOLO-AZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-10-08 | — | — | US | claimed |
| EP-3728262-B1 | TRIAZOLO-AZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-03-15 | — | — | EP | disclosed |
| US-11440915-B2 | Triazolo-azepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2022-09-13 | — | — | US | disclosed |
| EP-3728262-A1 | TRIAZOLO-AZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2020-10-28 | — | — | EP | disclosed |
| US-20200317681-A1 | TRIAZOLO-AZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-10-08 | — | — | US | disclosed |
| US-20200317681-A1 | TRIAZOLO-AZEPINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317681-A1 | TRIAZOLO-AZEPINE DERIVATIVES | HUWE1, APP, PSEN1 | APP 2/4885PSEN1 3/4885PSEN2 8/4885 |
| US-11440915-B2 | Triazolo-azepine derivatives | HUWE1, PSEN1, UPF1 | APP 4/4885PSEN1 2/4885PSEN2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.