HUWE1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL29357184	1.00	1/20
SCHEMBL14181325	0.54	1/20
SCHEMBL28144851	0.51	1/20
SCHEMBL473395	0.51	1/20
SCHEMBL4896185	0.50	1/20
SCHEMBL8851335	0.49	1/20
SCHEMBL10659701	0.49	1/20
SCHEMBL5025315	0.49	1/20
SCHEMBL10663909	0.48	1/20
SCHEMBL10665472	0.47	1/20
SCHEMBL473364	0.46	1/20
SCHEMBL473300	0.45	1/20
SCHEMBL473465	0.45	1/20
SCHEMBL11101788	0.44	1/20
SCHEMBL11026278	0.44	1/20
SCHEMBL4640793	0.44	1/20
SCHEMBL4640796	0.44	1/20
SCHEMBL473448	0.44	1/20
SCHEMBL27414407	0.44	1/20
SCHEMBL5099543	0.43	1/20

Clinical trials — most relevant to HUWE1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
LCL161 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis	PHASE2	COMPLETED
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study	PHASE2	WITHDRAWN
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Phase I Study of a Monoclonal Antibody for Treatment of Advanced Adenocarcinomas	PHASE1	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics	nan	UNKNOWN
Shwachman Diamond Syndrome Registry and Study	nan	RECRUITING
Using Mobile Technology to Improve Self-Regulation	nan	COMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
The Role of RING Ubiquitin Ligases in Biologic and Oncologic Processes in Tissues of Mesenchymal Origin	nan	UNKNOWN
Finding Genes With NGS Techniques in Whom Mutations Cause Neurological Diseases	nan	UNKNOWN
Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants	nan	RECRUITING
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS	nan	RECRUITING
Identification of the Genetic Causes of Rare Diseases With Negative Exome Findings	nan	UNKNOWN
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
Evaluating the Relationship of Morphine Consumption and Pain-related Molecules in Hepatic Surgical Patients	nan	COMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Identification of New FTLD Genes	nan	UNKNOWN
Exploring Novel Biomarkers of ICU-AW in Mechanically Ventilated Children at the Molecular Level	nan	ENROLLING_BY_INVITATION
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Use Massive Parallel Sequencing and Exome Capture Technology to Sequence the Exome of Fanconi Anemia Children and Their Patents	nan	AVAILABLE

Related proteins — ESM-2 sequence neighbours (a HUWE1 binder may also engage these)

Protein	Name	Similarity
Q7TMY8	—	1.000	Q7TMY8 →
P51593	—	1.000	P51593 →
Q8IZQ1	—	0.999	Q8IZQ1 →
Q6VNB8	—	0.993	Q6VNB8 →
Q5XPI4	—	0.992	Q5XPI4 →
A0A5F9C6I2	—	0.990	A0A5F9C6I2 →
Q5XPI3	—	0.990	Q5XPI3 →
D3ZXK7	—	0.989	D3ZXK7 →
F8VPU6	—	0.987	F8VPU6 →
Q6P4S8	—	0.987	Q6P4S8 →
P21359	—	0.987	P21359 →
F1R7R1	—	0.987	F1R7R1 →
Q5R6J0	—	0.985	Q5R6J0 →
O00507	—	0.985	O00507 →
TRRAP	Transformation/transcription domain-associated protein	0.983	landscape →
ECPAS	Proteasome adapter and scaffold protein ECM29	0.982	landscape →
O94915	—	0.982	O94915 →
A0A0R4ITC5	—	0.982	A0A0R4ITC5 →
P97526	—	0.982	P97526 →
P29994	—	0.982	P29994 →
Q9JLN9	—	0.981	Q9JLN9 →
Q86UW7	—	0.981	Q86UW7 →
A1L3F5	—	0.981	A1L3F5 →
Q8BYR5	—	0.981	Q8BYR5 →
Q91WR3	—	0.981	Q91WR3 →
Q04690	—	0.981	Q04690 →
Q9D486	—	0.981	Q9D486 →
O44431	—	0.981	O44431 →
Q9UPW5	—	0.980	Q9UPW5 →
Q8N201	—	0.980	Q8N201 →