Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.62 |
| ▸ | INSR | P06213 | 6/20 | 0.62 |
| ▸ | IGF1R | P08069 | 6/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | CD74 | P04233 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22520099 | 0.93 | EGFR (0.67) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL22497638 | 0.93 | EGFR (0.80) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL29253665 | 0.89 | JAK1 (0.57) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL22497639 | 0.89 | ALK (0.71) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL22497628 | 0.88 | EGFR (0.61) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL22520208 | 0.88 | EGFR (0.76) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL22520166 | 0.86 | EGFR (0.76) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL19027408 | 0.86 | ALK (0.58) | EGFRALKINSRIGF1RJAK2 | |
| SCHEMBL22520165 | 0.81 | JAK3 (0.63) | EGFRALKJAK2JAK1TYK2 | |
| SCHEMBL29253766 | 0.81 | JAK3 (0.56) | EGFRJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677680-A | EGFR inhibitor and composition and application thereof | 贝达药业股份有限公司 | 2021-11-19 | — | — | CN | claimed |
| CN-113677680-A | EGFR inhibitor and composition and application thereof | 贝达药业股份有限公司 | 2021-11-19 | — | — | CN | disclosed |
| WO-2020200191-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THERE OF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020200191-A1 | EGFR INHIBITORS, COMPOSITIONS AND METHODS THERE OF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2020-10-08 | — | — | WO | disclosed |