Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25194622 | 0.88 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL31158029 | 0.85 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL25114133 | 0.77 | KMT2A (0.49) | HPGDHTTTSHRMAPTPIM1 | |
| SCHEMBL16899342 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL4604780 | 0.75 | KDM4E (0.60) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL16225680 | 0.74 | ATAD2 (0.53) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL28647351 | 0.74 | NAMPT (0.44) | KDM4EALDH1A1MAPTPIM1PIM2 | |
| SCHEMBL1119372 | 0.73 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDATM | |
| SCHEMBL29562450 | 0.73 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDATM | |
| SCHEMBL505336 | 0.73 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10HPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113544129-A | Tricyclic compound preparation method and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020200284-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |