Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31158029 | 0.91 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL16899328 | 0.88 | OPRK1 (0.41) | KDM4EALDH1A1HSD17B10HPGDOPRK1 | |
| SCHEMBL29613526 | 0.82 | EZH2 (0.55) | OPRK1HDAC1HDAC2HDAC3PIM1 | |
| SCHEMBL13277356 | 0.82 | EZH2 (0.55) | OPRK1HDAC1HDAC2HDAC3PIM1 | |
| SCHEMBL25194622 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL22497869 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL29129117 | 0.76 | EZH2 (0.39) | KDM4EALDH1A1HSD17B10HPGDOPRK1 | |
| SCHEMBL16899382 | 0.76 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15711165 | 0.73 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10HPGDNPSR1 | |
| SCHEMBL16899368 | 0.73 | ALDH1A1 (0.41) | KDM4EALDH1A1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015104677-A1 | HETEROCYCLIC COMPOUNDS AS EZH2 INHIBITORS | Piramal Enterprises Limited (IN) | 2015-07-16 | — | — | WO | disclosed |