SCHEMBL22497961

SCHEMBL22497961

COC(=O)c1cc(C(F)(F)F)cc(C2(C#N)CC2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 2/20 0.52
▸ BDKRB1 P46663 1/20 0.39
▸ CNR1 P21554 1/20 0.38
▸ MEN1 O00255 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ CFTR P13569 1/20 0.36
▸ CES2 O00748 1/20 0.36
▸ HSD11B1 P28845 3/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ TRPM8 Q7Z2W7 1/20 0.35
▸ CA12 O43570 1/20 0.35
▸ CA1 P00915 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ CA7 P43166 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29659834 1.00 NOTUM (0.52) NOTUMBDKRB1CNR1MEN1NPC1
SCHEMBL22510351 0.86 NOTUM (0.40) NOTUMKDM4EALDH1A1MAPTTRPM8
SCHEMBL22497939 0.83 TRPM8 (0.43) MEN1NPC1RAB9AKMT2AALDH1A1
SCHEMBL29659833 0.83 TRPM8 (0.43) MEN1NPC1RAB9AKMT2AALDH1A1
SCHEMBL21609838 0.81 NOTUM (0.57) NOTUMCNR1KDM4EALDH1A1LMNA
SCHEMBL936363 0.81 CNR2 (0.41) BDKRB1MEN1NPC1RAB9AKMT2A
SCHEMBL29659839 0.80 NOTUM (0.56) NOTUMBDKRB1CNR1KDM4ELMNA
SCHEMBL22497949 0.80 NOTUM (0.56) NOTUMBDKRB1CNR1KDM4ELMNA
SCHEMBL21609774 0.80 NOTUM (0.56) NOTUMCNR1KDM4ELMNACFTR
SCHEMBL31646837 0.80 NOTUM (0.46) NOTUMMEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12527325-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2026-01-20 — — US disclosed
EP-3947358-B1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-06-18 — — EP disclosed
US-12281095-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2025-04-22 — — US disclosed
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-16 — — US disclosed
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-06-16 — — US disclosed
US-20220159958-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-05-26 — — US disclosed
US-20220159958-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2022-05-26 — — US disclosed
EP-3947359-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-02-09 — — EP disclosed
EP-3947358-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS Syngenta Crop Protection AG (CH) 2022-02-09 — — EP disclosed
CN-113661165-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-16 — — CN disclosed
CN-113631549-A Pesticidally active diazine-amide compounds 先正达农作物保护股份公司 2021-11-09 — — CN disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 — — WO disclosed
WO-2020201079-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 — — WO disclosed
WO-2020201398-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 — — WO disclosed
WO-2020201398-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12527325-B2 Pesticidally active diazine-amide compounds DDT, CHRM1, C3AR1 NOTUM 302/4885BDKRB1 290/4885CNR1 165/4885
US-20220185789-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 NOTUM 236/4885BDKRB1 3346/4885CNR1 1718/4885
US-12281095-B2 Pesticidally active diazine-amide compounds DDT, ACHE, NIT2 NOTUM 236/4885BDKRB1 3346/4885CNR1 1718/4885
US-20220159958-A1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS DDT, ACHE, NIT2 NOTUM 160/4885BDKRB1 3756/4885CNR1 2510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback