Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 6/20 | 0.40 |
| ▸ | SCD | O00767 | 4/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22505045 | 0.88 | NR1H2 (0.41) | BTKRIPK1 | |
| SCHEMBL29641539 | 0.88 | NR1H2 (0.41) | BTKRIPK1 | |
| SCHEMBL22504986 | 0.81 | NR1H2 (0.42) | RIPK1 | |
| SCHEMBL29641554 | 0.81 | NR1H2 (0.42) | RIPK1 | |
| SCHEMBL16783528 | 0.74 | ALDH1A1 (0.46) | ATMTP53 | |
| SCHEMBL16783636 | 0.74 | HPGD (0.34) | ATMTP53MAPK1 | |
| SCHEMBL16783631 | 0.73 | BRD4 (0.42) | TP53 | |
| SCHEMBL16783613 | 0.72 | ALDH1A1 (0.43) | TP53MAPK1 | |
| SCHEMBL16783443 | 0.71 | GABRP (0.43) | TP53 | |
| SCHEMBL16783614 | 0.69 | TP53 (0.45) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12527797-B2 | Isochromene derivatives as phosphoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2026-01-20 | — | — | US | disclosed |
| EP-3947384-B1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2023-11-01 | — | — | EP | disclosed |
| US-20220175784-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-09 | — | — | US | disclosed |
| EP-3947384-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-02-09 | — | — | EP | disclosed |
| CN-113874376-A | Isochromene derivatives as phosphoinositide 3-kinase inhibitors | 奇斯药制品公司 | 2021-12-31 | — | — | CN | disclosed |
| WO-2020200918-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220175784-A1 | ISOCHROMENE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | PIKFYVE, PDPK1, PIK3R5 | SCD5 2101/4885SCD 1269/4885BTK 196/4885 |
| US-12527797-B2 | Isochromene derivatives as phosphoinositide 3-kinases inhibitors | PIK3R5, PIK3CD, PIK3R4 | SCD5 2223/4885SCD 2156/4885BTK 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.