Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | CTSV | O60911 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22498482 | 0.91 | LRRK2 (0.52) | LRRK2CTSVCTSLGAAMEN1 | |
| SCHEMBL22498458 | 0.85 | NPC1 (0.51) | LRRK2GAAMEN1KMT2AMAPT | |
| SCHEMBL22498654 | 0.83 | NPC1 (0.51) | LRRK2GAAMEN1KMT2AMAPT | |
| SCHEMBL22498433 | 0.83 | LRRK2 (0.48) | LRRK2CTSVCTSLGAAMEN1 | |
| SCHEMBL22498539 | 0.82 | MAPT (0.48) | LRRK2GAAMEN1KMT2AMAPT | |
| SCHEMBL22498588 | 0.82 | LRRK2 (0.54) | LRRK2GAAMEN1KMT2AMAPT | |
| SCHEMBL22498480 | 0.82 | GAA (0.60) | LRRK2GAAMEN1KMT2AMAPT | |
| SCHEMBL22498469 | 0.80 | LRRK2 (0.46) | LRRK2CTSVCTSLGAAMEN1 | |
| SCHEMBL22498585 | 0.80 | LRRK2 (0.54) | LRRK2CTSVCTSLMEN1KMT2A | |
| SCHEMBL22498776 | 0.76 | LRRK2 (0.59) | LRRK2CTSVCTSLGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020201305-A1 | 4-(2,4-BIS(2-HYDROXYPHENYL)-1H-IMIDAZOL-1-YL)BENZOIC ACID DERIVATIVES AS NOVEL IRON CHELATORS | VIFOR (INTERNATIONAL) AG (CH) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020201305-A1 | 4-(2,4-BIS(2-HYDROXYPHENYL)-1H-IMIDAZOL-1-YL)BENZOIC ACID DERIVATIVES AS NOVEL IRON CHELATORS | VIFOR (INTERNATIONAL) AG (CH) | 2020-10-08 | — | — | WO | disclosed |