Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22498458 | 0.85 | NPC1 (0.51) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL22498654 | 0.83 | NPC1 (0.51) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL22498425 | 0.83 | TAS2R14 (0.46) | MEN1KMT2AGAATAS2R14SGMS2 | |
| SCHEMBL22498535 | 0.82 | LRRK2 (0.49) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL22498482 | 0.80 | LRRK2 (0.52) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL22498480 | 0.80 | GAA (0.60) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL22498433 | 0.77 | LRRK2 (0.48) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL22498469 | 0.74 | LRRK2 (0.46) | MAPTLMNAMEN1KMT2AGAA | |
| SCHEMBL22498588 | 0.73 | LRRK2 (0.54) | MAPTMEN1KMT2AGAAHTT | |
| SCHEMBL5017371 | 0.70 | AR (0.53) | MAPTLMNAGAASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020201305-A1 | 4-(2,4-BIS(2-HYDROXYPHENYL)-1H-IMIDAZOL-1-YL)BENZOIC ACID DERIVATIVES AS NOVEL IRON CHELATORS | VIFOR (INTERNATIONAL) AG (CH) | 2020-10-08 | — | — | WO | disclosed |