Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17281972 | 0.78 | LMNA (0.39) | LMNACYP2C9HSD11B1MAPK1 | |
| SCHEMBL12268260 | 0.78 | LMNA (0.39) | LMNACYP2C9HSD11B1MAPK1 | |
| SCHEMBL18745810 | 0.71 | HSD11B1 (0.33) | LMNACYP2C9HSD11B1 | |
| SCHEMBL27426225 | 0.71 | HSD11B1 (0.33) | LMNACYP2C9HSD11B1 | |
| SCHEMBL25507006 | 0.71 | HSD11B1 (0.33) | LMNACYP2C9HSD11B1 | |
| SCHEMBL24185585 | 0.71 | HSD11B1 (0.33) | LMNACYP2C9HSD11B1 | |
| SCHEMBL24652052 | 0.70 | MAPK1 (0.41) | LMNACYP2C9HSD11B1MAPK1 | |
| SCHEMBL278109 | 0.66 | LMNA (0.46) | LMNACYP2C9HSD11B1MAPK1 | |
| SCHEMBL16603050 | 0.66 | LMNA (0.46) | LMNACYP2C9HSD11B1MAPK1 | |
| SCHEMBL17057298 | 0.66 | LMNA (0.46) | LMNACYP2C9HSD11B1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3497091-B1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | LILLY CO ELI (US) | 2020-10-07 | — | — | EP | disclosed |