Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22508495 | 1.00 | AURKA (0.38) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL10444190 | 0.90 | HSD17B3 (0.42) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL22508372 | 0.90 | ALDH1A1 (0.38) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL10443992 | 0.90 | ALDH1A1 (0.38) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL20101895 | 0.90 | ALDH1A1 (0.38) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL10444152 | 0.79 | AURKA (0.40) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL10444032 | 0.79 | SRD5A1 (0.44) | SRD5A1NOTUMSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10444154 | 0.78 | ALDH1A1 (0.41) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL10444069 | 0.78 | ALDH1A1 (0.41) | AURKACHEK2CDK1PIM1FGFR1 | |
| SCHEMBL10444531 | 0.78 | SLC6A2 (0.30) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020205832-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020205835-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |