Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22508372 | 1.00 | ALDH1A1 (0.38) | ALDH1A1MAPTHPGDALOX12TDP1 | |
| SCHEMBL10443992 | 1.00 | ALDH1A1 (0.38) | ALDH1A1MAPTHPGDALOX12TDP1 | |
| SCHEMBL22508496 | 0.90 | AURKA (0.38) | HSD17B3AURKACHEK2CDK1PIM1 | |
| SCHEMBL22508495 | 0.90 | AURKA (0.38) | HSD17B3AURKACHEK2CDK1PIM1 | |
| SCHEMBL10444154 | 0.89 | ALDH1A1 (0.41) | ALDH1A1MAPTHPGDALOX12TDP1 | |
| SCHEMBL10444190 | 0.89 | HSD17B3 (0.42) | ALDH1A1MAPTHPGDALOX12TDP1 | |
| SCHEMBL10444069 | 0.86 | ALDH1A1 (0.41) | ALDH1A1MAPTHPGDALOX12TDP1 | |
| SCHEMBL22508366 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDALOX12TDP1 | |
| SCHEMBL10444499 | 0.84 | MAPT (0.39) | ALDH1A1MAPTHPGDALOX12TDP1 | |
| SCHEMBL20101878 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDALOX12TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287004-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2023-09-14 | — | — | US | disclosed |
| US-20220177487-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | NIKANG THERAPEUTICS, INC. | 2022-06-09 | — | — | US | disclosed |
| WO-2020205835-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020205832-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | NIKANG THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
| US-10633397-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | SHIONOGI & CO., LTD. (JP) | 2020-04-28 | — | — | US | disclosed |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230287004-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | ALDH1A1 1319/4885MAPT 4872/4885HPGD 2908/4885 |
| US-10633397-B2 | Substituted polycyclic pyridone derivatives and prodrugs thereof | C3AR1, NR4A1, HAVCR2 | ALDH1A1 1319/4885MAPT 4872/4885HPGD 2908/4885 |
| US-20220177487-A1 | FUSED POLYCYCLIC PYRIDONE COMPOUNDS AS INFLUENZA VIRUS REPLICATION INHIBITORS | PDXK, PNPO, CDKN1A | ALDH1A1 2966/4885MAPT 3329/4885HPGD 810/4885 |
| US-20180118760-A1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUGS THEREOF | C3AR1, NR4A1, HAVCR2 | ALDH1A1 1319/4885MAPT 4872/4885HPGD 2908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.