Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20755262 | 0.81 | ADORA2A (0.46) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL12305200 | 0.77 | ADORA1 (0.54) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL18481155 | 0.75 | ADORA1 (0.35) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL13866482 | 0.73 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL5732055 | 0.71 | TLR7 (0.43) | ADORA2AADORA1 | |
| SCHEMBL24081083 | 0.71 | LMNA (0.41) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL18165669 | 0.69 | CDK1 (0.60) | ADORA2AADORA1ADORA2B | |
| SCHEMBL2980005 | 0.68 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL23475880 | 0.66 | TLR7 (0.48) | — | |
| SCHEMBL12590752 | 0.66 | ADORA1 (0.46) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10981914-B2 | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor | Bristol-Myers Squibb Companay (US) | 2021-04-20 | — | — | US | disclosed |
| US-10927114-B2 | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-23 | — | — | US | disclosed |
| US-20200317672-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927114-B2 | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor | TLR7, TLR9, TLR1 | ADORA2A 176/4885ADORA1 112/4885HRH4 190/4885 |
| US-10981914-B2 | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor | TLR7, TLR1, TLR4 | ADORA2A 505/4885ADORA1 227/4885HRH4 157/4885 |
| US-20200317672-A1 | TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR | TLR7, TLR9, TLR1 | ADORA2A 176/4885ADORA1 112/4885HRH4 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.