Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.51 |
| ▸ | PI4KA | P42356 | 2/20 | 0.51 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.51 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.51 |
| ▸ | GAPDH | P04406 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.51 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22065053 | 1.00 | ADORA3 (0.51) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL19941913 | 0.92 | AHCY (0.47) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL22065156 | 0.90 | ADORA1 (0.45) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL20418959 | 0.90 | ADORA1 (0.45) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL21859250 | 0.90 | ADORA1 (0.45) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL15355255 | 0.90 | ADORA1 (0.45) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL29390219 | 0.90 | ADORA1 (0.45) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL9851766 | 0.89 | SLC29A1 (0.39) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL9851773 | 0.89 | SLC29A1 (0.39) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A | |
| SCHEMBL22036459 | 0.87 | ADORA1 (0.47) | ADORA3ADORA2BPI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947408-B1 | SALT OF TRIPHOSPHATE PHOSPHORAMIDATES OF NUCLEOTIDES AS ANTICANCER COMPOUNDS | NuCana plc (GB) | 2023-06-07 | — | — | EP | disclosed |
| WO-2020201751-A1 | SALT OF TRIPHOSPHATE PHOSPHORAMIDATES OF NUCLEOTIDES AS ANTICANCER COMPOUNDS | NuCana plc (GB) | 2020-10-08 | — | — | WO | disclosed |