Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 10/20 | 0.38 |
| ▸ | RAB9A | P51151 | 10/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156252 | 0.83 | ABCB1 (0.53) | ABCB1ABCC1NPC1RAB9AMAPT | |
| SCHEMBL12156211 | 0.81 | RAB9A (0.55) | ABCB1ABCC1NPC1RAB9AMAPT | |
| SCHEMBL12155497 | 0.80 | ABL1 (0.43) | ABCB1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12155603 | 0.80 | IL2 (0.43) | ABCB1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12241418 | 0.80 | NPC1 (0.52) | NPC1RAB9AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL12155615 | 0.80 | RAB9A (0.48) | ABCB1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12241435 | 0.79 | RAB9A (0.47) | ABCB1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12156212 | 0.79 | SMN1; SMN2 (0.48) | NPC1RAB9AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL12241433 | 0.79 | NPC1 (0.46) | ABCB1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12155618 | 0.79 | NPC1 (0.46) | ABCB1NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200317617-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | AVENUE CAPITAL MANAGEMENT II, L.P. | 2020-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200317617-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | ABCB1 1679/4885ABCC1 1380/4885POLQ 4725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.