Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCK1 | P16333 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30908485 | 1.00 | NCK1 (0.48) | NCK1BACE1CYP1A2ALDH1A1LMNA | |
| SCHEMBL22509690 | 0.85 | NCK1 (0.53) | NCK1BACE1CYP1A2ALDH1A1KMT2A | |
| SCHEMBL22509810 | 0.80 | CYP1A2 (0.52) | NCK1BACE1CYP1A2ALDH1A1LMNA | |
| SCHEMBL30908292 | 0.77 | KMT2A (0.59) | NCK1BACE1CYP1A2ALDH1A1LMNA | |
| SCHEMBL18571529 | 0.77 | BACE1 (0.55) | BACE1CYP1A2ALDH1A1LMNAKMT2A | |
| SCHEMBL22509740 | 0.77 | KMT2A (0.50) | NCK1BACE1CYP1A2ALDH1A1LMNA | |
| SCHEMBL18571743 | 0.77 | NCK1 (0.48) | NCK1BACE1CYP1A2ALDH1A1LMNA | |
| SCHEMBL24254157 | 0.77 | NPC1 (0.42) | BACE1ALDH1A1LMNAPOLBGAA | |
| SCHEMBL22521405 | 0.77 | ALOX5AP (0.41) | BACE1ALDH1A1LMNAGAAKMT2A | |
| SCHEMBL22509693 | 0.74 | NCK1 (0.46) | NCK1BACE1CYP1A2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024074611-A1 | PRMT5 INHIBITORS | Ryvu Therapeutics S.A. (PL) | 2024-04-11 | — | — | WO | disclosed |
| WO-2020205867-A1 | COMPOUNDS TARGETING PRMT5 | ALIGOS THERAPEUTICS, INC. (US) | 2020-10-08 | — | — | WO | disclosed |