SCHEMBL2251

SCHEMBL2251

CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)OC)C(C)C

nearest known ligand 0.73

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 13/20 0.73
LTB4R2 Q9NPC1 9/20 0.59
ABCB11 O95342 1/20 0.59
GP6 Q9HCN6 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2252 1.00 AGTR1 (0.73) AGTR1LTB4R2ABCB11GP6
SCHEMBL2373 1.00 AGTR1 (0.73) AGTR1LTB4R2ABCB11GP6
SCHEMBL29669823 1.00 AGTR1 (0.73) AGTR1LTB4R2ABCB11GP6
SCHEMBL2353 0.94 AGTR1 (0.65) AGTR1LTB4R2ABCB11GP6
SCHEMBL683543 0.94 AGTR1 (0.64) AGTR1LTB4R2ABCB11GP6
SCHEMBL4473044 0.93 AGTR1 (0.64) AGTR1LTB4R2ABCB11GP6
SCHEMBL2758 0.93 AGTR1 (0.64) AGTR1LTB4R2ABCB11GP6
SCHEMBL8476198 0.93 AGTR1 (0.64) AGTR1LTB4R2ABCB11GP6
SCHEMBL24998852 0.92 AGTR1 (0.63) AGTR1LTB4R2ABCB11GP6
SCHEMBL21125607 0.92 AGTR1 (0.63) AGTR1LTB4R2ABCB11GP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3822259-B1 METHOD FOR SYNTHESIZING VALSARTAN ZHEJIANG HUAHAI PHARM CO LTD (CN) 2025-08-27 EP claimed
CN-112638885-B Synthesis method of valsartan 浙江华海药业股份有限公司 2024-06-11 CN claimed
CN-117886767-A Synthesis method of N-methyl substituted valsartan impurity 珠海润都制药股份有限公司 2024-04-16 CN claimed
CN-115160247-A Method for recycling methyl ester from valsartan mother liquor 江苏新瑞药业有限公司 2022-10-11 CN claimed
CN-115160246-A Process for recovering valsartan from valsartan mother liquor 江苏新瑞药业有限公司 2022-10-11 CN claimed
US-11434210-B2 Method for synthesizing valsartan ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) 2022-09-06 US claimed
CN-113264891-A Method for recovering L-valsartan from valsartan mother liquor containing D-valsartan 珠海润都制药股份有限公司 2021-08-17 CN claimed
EP-3822259-A1 METHOD FOR SYNTHESIZING VALSARTAN Zhejiang Huahai Pharmaceutical Co., Ltd. (CN) 2021-05-19 EP claimed
CN-112641773-A Composition containing heterocyclic compound and use thereof 黄泳华 2021-04-13 CN claimed
CN-112638885-A Synthesis method of valsartan 浙江华海药业股份有限公司 2021-04-09 CN claimed
CN-111265518-A Composition containing a mixture of biphenyl derivatives and uses thereof 黄泳华 2020-06-12 CN claimed
WO-2020010643-A1 METHOD FOR SYNTHESIZING VALSARTAN 浙江华海药业股份有限公司 2020-01-16 WO claimed
CN-103923028-B Preparation method of valsartan methyl ester 青岛雪洁助剂有限公司 2017-05-24 CN claimed
CN-106038499-A Valsartan dispersible tablet and preparation method thereof 深圳市樊溪电子有限公司 2016-10-26 CN claimed
CN-103012301-B Valsartan methyl ester alkali metal salt and preparation method thereof JIANGSU SHIMEIKANG PHARMACEUTICAL CO LTD 2015-06-17 CN claimed
CN-102649780-A Improved process for synthesizing valsartan GUANGDONG HEC PHARMACEUTICAL 2012-08-29 CN claimed
CN-102321038-A Improved valsartan preparation method ANHUI PROVINCE HONG SHENG BIO TECHNOLOGY CO LTD 2012-01-18 CN claimed
WO-2010091169-A2 PREPARATION OF VALSARTAN DR. REDDY'S LABORATORIES LTD. (IN) 2010-08-12 WO claimed
EP-0443983-B1 Acyl compounds CIBA GEIGY AG (CH) 1996-02-28 EP claimed
EP-0443983-A1 Acyl compounds CIBA-GEIGY AG (CH) 1991-08-28 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11434210-B2 Method for synthesizing valsartan REN, ACE, AGT AGTR1 8/4885LTB4R2 3722/4885ABCB11 1504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.