Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 7/20 | 0.43 |
| ▸ | RARA | P10276 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2741574 | 0.83 | ESR1 (0.37) | RARBRARACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2847898 | 0.82 | ESR1 (0.45) | RARBRARACYP2C9CYP2C19CYP3A4 | |
| SCHEMBL1533776 | 0.82 | RARB (0.42) | RARBRARACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1533757 | 0.82 | RARB (0.40) | RARBRARACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11015662 | 0.81 | RARB (0.50) | RARBCYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL1533759 | 0.81 | RARB (0.44) | RARBRARARARGTSHR | |
| SCHEMBL1533783 | 0.81 | RARB (0.47) | RARBRARACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11015078 | 0.80 | CYP2D6 (0.49) | RARBCYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL11014654 | 0.80 | CYP2D6 (0.49) | RARBCYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL11016069 | 0.80 | CYP2D6 (0.49) | RARBCYP1A2CYP2D6CYP19A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486297-B2 | Thiophene derivatives, and LC media comprising same | MERCK PATENT GMBH (DE) | 2013-07-16 | — | — | US | disclosed |
| US-8486297-B2 | Thiophene derivatives, and LC media comprising same | MERCK PATENT GMBH (DE) | 2013-07-16 | — | — | US | disclosed |
| US-8394293-B2 | Thiophene derivatives, and LC media containing same | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-03-12 | — | — | US | disclosed |
| US-8394293-B2 | Thiophene derivatives, and LC media containing same | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-03-12 | — | — | US | disclosed |
| EP-2398787-B1 | Thiophene derivates and liquid crystal media comprising the same | MERCK PATENT GMBH (DE) | 2013-01-30 | — | — | EP | disclosed |
| EP-2265692-B1 | THIOPHENE DERIVATIVES, AND LC MEDIA CONTAINING THE SAME | MERCK PATENT GMBH (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-05 | — | — | US | disclosed |
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-01-05 | — | — | US | disclosed |
| EP-2398787-A1 | THIOPHENE DERIVATES AND LIQUID CRYSTAL MEDIA COMPRISING THE SAME | Merck Patent GmbH (DE) | 2011-12-28 | — | — | EP | disclosed |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-03 | — | — | US | disclosed |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-03 | — | — | US | disclosed |
| EP-2265692-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA CONTAINING THE SAME | Merck Patent GmbH (DE) | 2010-12-29 | — | — | EP | disclosed |
| WO-2010099853-A1 | THIOPHENE DERIVATES AND LIQUID CRYSTAL MEDIA COMPRISING THE SAME | MERCK PATENT GMBH (DE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2009129915-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA CONTAINING THE SAME | MERCK PATENT GMBH (DE) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120001123-A1 | THIOPHENE DERIVATIVES, AND LC MEDIA COMPRISING SAME | TEC, TPMT, TST | RARB 3907/4885RARA 3956/4885CYP1A2 2102/4885 |
| US-20110049427-A1 | Thiophene derivatives, and LC media containing same | TPMT, TEC, LCT | RARB 3984/4885RARA 4056/4885CYP1A2 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.