Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26449379 | 0.89 | MMP13 (0.39) | CRBNDDB1AURKBMAPTALOX5 | |
| SCHEMBL22534759 | 0.88 | CRBN (0.46) | CRBNDDB1AURKBMAPTALOX5 | |
| SCHEMBL22534808 | 0.86 | CRBN (0.44) | CRBNDDB1AURKBMAPTKDM4E | |
| SCHEMBL22534797 | 0.86 | CRBN (0.46) | CRBNDDB1AURKBALOX5MEN1 | |
| SCHEMBL30483684 | 0.86 | CRBN (0.46) | CRBNDDB1AURKBALOX5ROCK2 | |
| SCHEMBL22534760 | 0.86 | CRBN (0.46) | CRBNDDB1MAPTALOX5MMP13 | |
| SCHEMBL22534722 | 0.86 | CRBN (0.46) | CRBNDDB1AURKBALOX5ROCK2 | |
| SCHEMBL30483679 | 0.86 | CRBN (0.46) | CRBNDDB1AURKBALOX5ROCK2 | |
| SCHEMBL22534810 | 0.85 | CRBN (0.43) | CRBNDDB1AURKBROCK2EGFR | |
| SCHEMBL22534724 | 0.85 | CRBN (0.43) | CRBNDDB1ROCK2EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230138411-A1 | PYRIMIDINE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-05-04 | — | — | US | disclosed |
| US-20230138411-A1 | PYRIMIDINE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-05-04 | — | — | US | disclosed |
| EP-3630729-B1 | PYRIMIDINE COMPOUND | OTSUKA PHARMA CO LTD (JP) | 2021-11-03 | — | — | EP | disclosed |
| US-20200399245-A1 | PYRIMIDINE COMPOUND | OTSUKA PHARMACEUTICAL CO, LTD. (JP) | 2020-12-24 | — | — | US | disclosed |
| US-10800758-B2 | Pyrimidine compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230138411-A1 | PYRIMIDINE COMPOUND | UMPS, TPMT, TYMS | CRBN 4450/4885DDB1 2854/4885AURKB 1954/4885 |
| US-20200399245-A1 | PYRIMIDINE COMPOUND | UMPS, TPMT, TYMS | CRBN 4450/4885DDB1 2854/4885AURKB 1954/4885 |
| US-10800758-B2 | Pyrimidine compound | UMPS, TPMT, TYMS | CRBN 4450/4885DDB1 2854/4885AURKB 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.