Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 10/20 | 0.45 |
| ▸ | PDE2A | O00408 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22550831 | 0.85 | PDE2A (0.42) | PDE2AJAK2JAK1JAK3 | |
| SCHEMBL22550825 | 0.84 | PDE2A (0.39) | PDE2AJAK2JAK1JAK3 | |
| SCHEMBL22550926 | 0.83 | PDE2A (0.38) | PDE2AJAK2JAK1JAK3 | |
| SCHEMBL21200772 | 0.80 | RBP4 (0.46) | CBLBHTR2AHTR2CSLC6A4KDM4E | |
| SCHEMBL23023546 | 0.78 | JAK2 (0.45) | PDE2AJAK2JAK1JAK3 | |
| SCHEMBL13769311 | 0.77 | HCAR2 (0.43) | CBLBHTR2AHTR2CSLC6A4KDM4E | |
| SCHEMBL21199919 | 0.77 | RBP4 (0.44) | CBLBKDM4EGRM5 | |
| SCHEMBL21200298 | 0.76 | LMNA (0.41) | CBLBHTR2AHTR2CSLC6A4 | |
| SCHEMBL22695511 | 0.75 | CBLB (0.57) | CBLB | |
| SCHEMBL21200043 | 0.74 | HCAR2 (0.46) | CBLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210508-A1 | 3-SUBSTITUTED PIPERIDINE COMPOUNDS FOR CBL-B INHIBITION, AND USE OF A CBL-B INHIBITOR IN COMBINATION WITH A CANCER VACCINE AND/OR ONCOLYTIC VIRUS | NURIX THERAPEUTICS, INC. (US) | 2020-10-15 | — | — | WO | disclosed |