Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | PRKX | P51817 | 2/20 | 0.44 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251813 | 0.86 | POLB (0.45) | POLBROCK2ROCK1P2RX7ULK1 | |
| SCHEMBL2252066 | 0.83 | POLB (0.44) | POLBROCK2ROCK1P2RX7ULK1 | |
| SCHEMBL2252297 | 0.78 | MAPK1 (0.44) | POLBROCK2ROCK1P2RX7NPC1 | |
| SCHEMBL2252687 | 0.76 | DHODH (0.50) | POLBROCK2ROCK1P2RX7NPC1 | |
| SCHEMBL12457421 | 0.76 | CYP1A2 (0.48) | POLBROCK2ROCK1P2RX7ULK1 | |
| SCHEMBL13758637 | 0.75 | P2RX7 (0.40) | POLBROCK2ROCK1P2RX7ULK1 | |
| SCHEMBL5401667 | 0.74 | CYP2D6 (0.47) | ROCK2ROCK1NPC1RAB9ARPS6KB1 | |
| SCHEMBL2254728 | 0.73 | DHODH (0.55) | POLBROCK2ROCK1P2RX7NPC1 | |
| SCHEMBL2253121 | 0.73 | DHODH (0.49) | POLBROCK2ROCK1P2RX7NPC1 | |
| SCHEMBL13758459 | 0.72 | P2RX7 (0.39) | POLBROCK2ROCK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254884-B1 | 3-ALKYL-PIPERAZINE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2013-05-01 | — | — | EP | disclosed |
| EP-2254884-B1 | 3-ALKYL-PIPERAZINE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2013-05-01 | — | — | EP | disclosed |
| US-7998963-B2 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998963-B2 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998963-B2 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20090209553-A1 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-08-20 | — | — | US | disclosed |
| US-20090209553-A1 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-08-20 | — | — | US | disclosed |
| US-20090209553-A1 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-08-20 | — | — | US | disclosed |
| WO-2009101018-A2 | 3-ALKYL-PIPERAZINE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209553-A1 | Arylpiperazine derivatives and uses thereof | ADRA2C, AHR, CYP1A2 | POLB 4117/4885ROCK2 2835/4885ROCK1 3778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.