Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12883183 | 1.00 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HSD11B1FFAR3CETP | |
| SCHEMBL7968390 | 0.97 | FFAR3 (0.38) | ALDH1A1SMN1; SMN2HSD11B1FFAR3CETP | |
| SCHEMBL27878705 | 0.92 | — | — | |
| SCHEMBL8025488 | 0.87 | — | — | |
| SCHEMBL7080172 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HSD11B1FFAR3CETP | |
| SCHEMBL7080167 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HSD11B1FFAR3CETP | |
| SCHEMBL16887657 | 0.79 | POLB (0.34) | FFAR3LMNA | |
| SCHEMBL8536096 | 0.79 | LMNA (0.39) | ALDH1A1SMN1; SMN2HSD11B1FFAR3CYP2C19 | |
| SCHEMBL21238456 | 0.78 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HSD11B1FFAR3CETP | |
| SCHEMBL561450 | 0.78 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2HSD11B1FFAR3CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020210630-A1 | TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS | C4 THERAPEUTICS, INC. (US) | 2020-10-15 | — | — | WO | disclosed |