SCHEMBL2255346

SCHEMBL2255346

CCC(=O)c1cccc(Cl)c1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERCC5 P28715 2/20 0.61
FEN1 P39748 2/20 0.61
TSHR P16473 1/20 0.59
TAS1R3 Q7RTX0 1/20 0.56
TAS1R1 Q7RTX1 1/20 0.56
TAS1R2 Q8TE23 1/20 0.56
MGAM O43451 1/20 0.47
AMY1A P0DUB6 1/20 0.47
GAA P10253 1/20 0.47
SI P14410 1/20 0.47
MGAM2 Q2M2H8 1/20 0.47
F2R P25116 1/20 0.47
P2RX7 Q99572 3/20 0.46
JAK2 O60674 1/20 0.44
SLC6A2 P23975 2/20 0.43
SLC6A4 P31645 2/20 0.43
SLC6A3 Q01959 2/20 0.43
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
MEN1 O00255 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8166175 0.85 ERCC5 (0.57) ERCC5FEN1TSHRTAS1R3TAS1R1
SCHEMBL2837238 0.83 ERCC5 (0.58) ERCC5FEN1CES2CES1MEN1
SCHEMBL1262256 0.82 KLKB1 (0.47) ERCC5FEN1TSHRTAS1R3TAS1R1
SCHEMBL10769427 0.82 HSP90AB1 (0.47) ERCC5FEN1TSHRTAS1R3TAS1R1
SCHEMBL28159519 0.82 LMNA (0.46) ERCC5FEN1TSHRTAS1R3TAS1R1
SCHEMBL28877415 0.82 ERCC5 (0.54) ERCC5FEN1TSHRTAS1R3TAS1R1
Hydrochloric Acid SCHEMBL30461901 0.82 ERCC5 (0.56) ERCC5FEN1CES2CES1MEN1
SCHEMBL28385050 0.82 HSP90AB1 (0.46) ERCC5FEN1TSHRTAS1R3TAS1R1
Water SCHEMBL7994046 0.82 ERCC5 (0.56) ERCC5FEN1CES2CES1MEN1
SCHEMBL3142115 0.82 ERCC5 (0.62) ERCC5FEN1TSHRTAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115436507-A Method for detecting content of 3,4' -dichloropropiophenone 山东京博生物科技有限公司 2022-12-06 CN claimed
CN-111454137-B Synthetic method for improving yield of 5-chloro-1-indanone 山东京博生物科技有限公司 2022-09-23 CN claimed
CN-111454137-A Synthetic method for improving yield of 5-chloro-1-indanone 山东京博生物科技有限公司 2020-07-28 CN claimed
CN-111205175-A Synthetic method for improving yield of 5-chloro-1-indanone 京博农化科技有限公司 2020-05-29 CN claimed
CN-106083686-B The method of alpha-brominated acetophenone oxime ether synthesis 2,4- diaryl pyrrole class compound 苏州大学 2019-01-22 CN claimed
CN-107118103-A A kind of insecticide indoxacarb intermediate and its synthesis technique 连云港市国盛化工有限公司 2017-09-01 CN claimed
CN-103601625-A Method for producing 5-chloro-1-indanone JIANGYAN KEYAN FINE CHEMICAL CO LTD 2014-02-26 CN claimed
CN-101302552-B Method for preparing (R)-2-chlorin-1-(3-chlorphenyl) ethanol by microorganism catalysis CHONGQING PORTON TECHNOLOGY CO LTD 2010-12-29 CN claimed
CN-101302552-A Method for preparing (R)-2-chlorin-1-(3-chlorphenyl) ethanol by microorganism catalysis CHONGQING PORTON TECHNOLOGY CO (CN) 2008-11-12 CN claimed
CN-1403434-A Prepn process of 5-chloro-2,3-dihydro-1-indenone WANG MINGCHUN (CN) 2003-03-19 CN claimed
CN-115436507-A Method for detecting content of 3,4' -dichloropropiophenone 山东京博生物科技有限公司 2022-12-06 CN disclosed
CN-111454137-B Synthetic method for improving yield of 5-chloro-1-indanone 山东京博生物科技有限公司 2022-09-23 CN disclosed
CN-113234062-B Pyrazinylimidazole compound, weldable protective agent, preparation method and application of pyrazinylimidazole compound and weldable protective agent 赣州市贝加尔电子材料有限公司 2022-07-08 CN disclosed
CN-111057043-B Imidazole compound, preparation method and application thereof, organic weldable protective agent containing imidazole compound and surface treatment method 深圳市贝加电子材料有限公司 2021-11-02 CN disclosed
CN-113234062-A Pyrazinylimidazole compound, weldable protective agent, preparation method and application of pyrazinylimidazole compound and weldable protective agent 赣州市贝加尔电子材料有限公司 2021-08-10 CN disclosed
US-5096902-A Cerebral antihypoxic action, senile dememtia, Alzheimer's, cognitive functions RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 1992-03-17 US disclosed
EP-0462264-A1 HETEROCYCLIC DERIVATIVES, METHOD FOR PREPARING SAME, AND THEIR THERAPEUTIC APPLICATIONS AS PAF-ANTAGONISTS. SANOFI SA (FR) 1991-12-27 EP disclosed
WO-1991009857-A1 HETEROCYCLIC DERIVATIVES, METHOD FOR PREPARING SAME, AND THEIR THERAPEUTIC APPLICATIONS SANOFI (FR) 1991-07-11 WO disclosed
CN-1049159-A The heterogeneous ring compound of new nitrogenous and sulphur, the method that contains the pharmaceutical composition of this compounds and prepare them RICHTER GEDEON VEGYESZET (HU) 1991-02-13 CN disclosed
EP-0144729-A1 11-Substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines, a process for their preparation and their use in medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1985-06-19 EP disclosed